'Adult'-type Leydig cells differentiate in the post-natal testis and are quiescent until puberty. They are preceded in the testis by a population of 'fetal'-type Leydig cells from the 8th to the 20th week of gestation, which produce enough testosterone for masculinisation of a male fetus.MeSH: D007985. Differentiation of adult Leydig cells. Benton L(1), Shan LX, Hardy MP. Author information: (1)Population Council, New York, NY 10021, USA. Adult Leydig cells originate within the testis postnatally. Their formation is a continuous process involving gradual transformation of progenitors into Cited by: 256.
Mar 08, 2016 · Testicular Leydig cells are the primary source of testosterone in males. Adult Leydig cells have been shown to arise from stem cells present in the neonatal testis. Once established, adult Leydig cells turn over only slowly during adult life, but when these cells are eliminated experimentally from the adult testis, new Leydig cells rapidly Cited by: 65. Apr 16, 2019 · Leydig cells play a pivotal function in the synthesis of a male sex steroid, testosterone. The ability of the steroid production is dependent on the expression of the steroidogenic genes, such as HSD3B (3β-hydroxysteroid dehydrogenase/Δ5- Δ4 isomerase). It has been established that two different types of Leydig cells, fetal Leydig cells (FLCs) and adult Leydig cells (ALCs), are developed in Cited by: 1.
Apr 17, 2019 · This would certainly be consistent with the failure of adult Leydig cell markers to increase after hCG. Recent studies have shown, however, that while there is a relative increase in fetal Leydig cells in the adult ARKO mouse, adult Leydig cells still outnumber fetal Leydig cells by a Author: Peter J. O’Shaughnessy, Rod T. Mitchell, Ana Monteiro, Laura O’Hara, Lyndsey Cruickshanks, Hedi Claa. Jan 01, 2019 · The EDS-treated regeneration of Leydig cells is a unique model for the investigation of the proliferation and differentiation of stem and progenitor Leydig cells in the adult-testis. Leydig cells in the adult-testis completely disappear after a rat is injected intraperitoneally a Author: Yao Lv, Yinghui Fang, Panpan Chen, Yue Duan, Tongliang Huang, Leikai Ma, Lubin Xie, Xianwu Chen, Xia.
Dec 01, 2018 · Previous studies have established that fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) show distinct functional characteristics. However, the lineage relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal stage. Moreover, the dedifferentiated cells contribute to the Cited by: 4. The Sertoli cells are critical regulators of testis differentiation and development. In the adult, however, their known function is restricted largely to maintenance of spermatogenesis. To determine whether the Sertoli cells regulate other aspects of adult testis biology we have used a novel transgenic mouse model in which Amh-Cre induces expression of the receptor for Diphtheria toxin (iDTR.